Oscillogy is the exclusive manufacturer and supplier of the MIGET by MMIMS system, a novel new approach to the multiple inert gas elimination technique (MIGET) that offers the benefits of small blood sample volumes, rapid analysis time, and automated sample handling.   The multiple inert gas elimination technique is a method for measuring distributions of ventilation/perfusion ratios (V/Q ratios) in the lung (13,19). Developed by Drs. Peter Wagner and John West at the University of San Diego in the 1970s (16-18), the MIGET has been used in dozens of studies to define the underlying gas exchange pathophysiology in COPD (9,10), asthma (14,15), ARDS (4,11), pulmonary embolism (3,5), general anesthesia (8,12), and many experimental models of lung diseases. The technical demands of measuring the inert gas partial pressures in blood samples by gas chromatography, however, have limited the application of traditional MIGET to very specialized research laboratories.   Micropore membrane inlet mass spectrometery (MMIMS) is a proprietary mass spectrometer inlet technology ideally suited to measurement of dissolved gas partial pressures in small liquid samples. The MMIMS technology was developed at the University of Pennsylvania (2) and is currently licensed by Oscillogy for the MIGET by MMMS application.    Since its founding in 2003, Oscillogy has been intensely involved in the advancement of the MIGET by MMIMS technology from a laboratory bench version, first demonstrated in 2000 (1), to a completely automated commercial product for use in the broader research community. An early prototype was delivered to the laboratory of Dr. Klaus Markstaller at Johannes Gutenberg University in Mainz, Germany in 2005. The capabilities of this early prototype have been described in a small series of publications (6,7). A second prototype was delivered to the laboratory of Dr. Balthasar Eberle and Dr. Sebastien Trachsel in Bern, Switzerland in 2007.   In March of 2009 these early prototypes underwent a major upgrade from a single-pore MMIMS probe to multi-pore MMIMS probes, a key development that increased the signal to noise ratio by a factor of approximately 400. A second major recent upgrade updated the control software to make system operation nearly completely automated.